1. Margaret Spencer m. Anthony Ashley Cooper, 1st Earl of Shaftsbury. This is her ancestry:
2. John Spencer (b. abt 1437- d. 1552) m. Jane Graunt (b. 1465- d. 1498). Their son:
3. William Spencer (b. 1496- d. 1532) m. Susan Knightly (b. 1498- d. 1532). Their son:
4. John Spencer (b. 1517- d. 1586) m. Catherine Kitson (b. 1521- d. 1586). Their son:
5. John Spencer (b. 1546- d. 1599) m. Mary Catlyn (b. 1555- d. 1615). Their son:
6. Robert Spencer (b. 1570- d. abt 1597) m. Margaret Willoughby (b. 1571- d. 1597). Their children: Mary Spencer (b. 1588 England) and
7. William Spencer (b. 1591 Anthrop, Northamptonshire, England- d. 1636 Brington, Northamptonshire, England) m. 1615 Tichfield, England to Penelope Wriothlesley (1598). Their daughter:
8. Margaret Spencer
2. John Spencer (b. abt 1437- d. 1552) m. Jane Graunt (b. 1465- d. 1498). Their son:
3. William Spencer (b. 1496- d. 1532) m. Susan Knightly (b. 1498- d. 1532). Their son:
4. John Spencer (b. 1517- d. 1586) m. Catherine Kitson (b. 1521- d. 1586). Their son:
5. John Spencer (b. 1546- d. 1599) m. Mary Catlyn (b. 1555- d. 1615). Their son:
6. Robert Spencer (b. 1570- d. abt 1597) m. Margaret Willoughby (b. 1571- d. 1597). Their children: Mary Spencer (b. 1588 England) and
7. William Spencer (b. 1591 Anthrop, Northamptonshire, England- d. 1636 Brington, Northamptonshire, England) m. 1615 Tichfield, England to Penelope Wriothlesley (1598). Their daughter:
8. Margaret Spencer